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Structures and technology for biologists.

Thomas C Terwilliger1

  • 1Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA. terwilliger@LANL.gov

Nature Structural & Molecular Biology
|March 30, 2004
PubMed
Summary
This summary is machine-generated.

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Structural genomics is accelerating the discovery of new macromolecular structures. This progress will drive the development of automated methods and benefit all biological sciences.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Genomics

Background:

  • Structural genomics initiatives are a major source of novel macromolecular structures.
  • These efforts focus on determining structures with less than 30% sequence identity to known ones.
  • The field is advancing systematic and automated structure determination techniques.

Purpose of the Study:

  • To highlight the impact of structural genomics on macromolecular structure determination.
  • To emphasize the development of new technologies and infrastructure in structural biology.
  • To underscore the broad benefits of these advancements for the biological sciences.

Main Methods:

  • Analysis of structural genomics output.
  • Tracking the development of automated structure determination technologies.

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  • Forecasting the impact of future structural data and technologies.

    • Main Results:

    • Structural genomics currently provides a quarter of all newly determined macromolecular structures.
    • These efforts are spurring advancements in systematic and automated structure determination.
    • Anticipation of thousands of new structures and enhanced capabilities in the coming decade.

    Conclusions:

    • Structural genomics is a key driver of innovation in structural biology.
    • The ongoing development of technologies will significantly enhance biological research.
    • The future holds substantial benefits for all biologists through expanded structural data and methodologies.