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Horse antilymphocytic globulin in hepatitis B exacerbation after bone marrow transplantation adoptive immunity

C Favre1, M C Menconi, M Nardi

  • 1Unità Trapianto di Midollo, Clinica Pediatrica I, Via Roma 67, 56126 Pisa, Italy. c.favre@med.unipi.it

Bone Marrow Transplantation
|March 30, 2004
PubMed

We describe the case of a HBsAg+, HBeAg+ carrier, treated with lamivudine, who experienced exacerbation of hepatitis after BMT from an anti-HBs+, anti-HBc+, anti-HBe+ donor. The serological profile of the donor and the timing of exacerbation suggested that the adoptive immunity transfer played a major pathogenetic role. Antilymphocyte globulin administration resulted in resolution of hepatitis and seroconversion to anti-HBs+. Therapy aimed at blocking the effector arm of liver damage could represent a novel approach to avoid the risk of progression to fulminant hepatitis without hampering the chances of recovery from hepatitis B.

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