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[Studies of radiosensitizative effect of BSO on Acc-2 cells]
1Department of Oral & Maxillofacial Surgery, School of Stomatology, Shanghai Second Medical University. Shanghai 200011 China.
Abstract:
OBJECTIVE:To study the radiosensitizative effect of buthione sulfoximin (BSO) on Acc-2 cells.METHODS:First,the pharmotoxicity of BSO to Acc-2 cells under hypoxic or aerobic conditions was measured.Second,the radiosensitizative effect of BSO on Acc-2 cells under hypoxic or aerobic conditions was studied.Plating efficiency assay was used in this experiment.RESUTS:The 50% inhibition dose (ID50) of BSO to Acc-2 cells under hypoxic or aerobic condition was 80 micromol/L,120micromol/L,respectively.When the dose of BSO was ID20 and ID10 under hypoxic or aerobic condition the SER was 1.521,1.263 and 1.296,1.153,respectively.CONCLUSION:BSO had radiosensitizative effect on Acc-2 cells both under hypoxic or aerobic condition.The radiosensitizative effect of BSO on Acc-2 cells under hypoxic condition was stronger than that under aerobic condition.
