[A study of the mitogen effects of endothelin-1 on human dental pulp cell in vitro]

OBJECTIVE:To investigate the mitogen effects of endothelin-1 (ET-1)with different concentrations on human pulp cells.METHODS:Using in vitro pulp cell cultrue technique and thiazolyl blue tetrazolium bromide (MTT) staining and spectrophotometric assay.RESULTS:Endothelin-1 with different concentration had the mitogenesis on human pulp cells in different degree,which was dependent on ET-1 concentration.CONCLUSION:Endothelin-1 which was mitogen factor on human pulp cells may play a role in the regeneration of pulp tissue.