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Involvement of hypothalamic noradrenergic systems in the modulation of intestinal motility in rats
B Bonaz1, L Martin, E Beurriand
1Laboratoire de Physiologie, Institut National de la Santé et de la Recherche Médicale, U318, Grenoble, France.
Brain Research
|June 26, 1992
Abstract:
Selective lesions of the noradrenergic systems of the paraventricular nucleus (PVN) of the hypothalamus with 6-hydroxydopamine (6-OHDA) lengthen the periodicity of the migrating myoelectric complex (MMC), an index of intestinal motility, in rats. These lengthening effects resemble those obtained after lesions of the locus coeruleus (LC), thus suggesting that noradrenergic terminals from LC to the PVN are involved in this modulation.