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Polymorphism at codon 469 of the intercellular adhesion molecule-1 gene is not associated with sporadic Alzheimer's

Lucía Rodero1, Jon Infante, Enrique Palacio

  • 1Neurology Service, University Hospital Marqués de Valdecilla, University of Cantabria, 39008-Santander, Spain.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
|March 30, 2004
PubMed

Insights

This study investigated the ICAM-1 gene polymorphism

Area of Science:

  • Neuroscience
  • Genetics
  • Immunology

Background:

  • Microglial activation is central to Alzheimer's disease (AD) chronic inflammation.
  • Intercellular adhesion molecule-1 (ICAM-1) may link microglia to amyloid plaques in AD.
  • A prior Italian study suggested an ICAM-1 gene polymorphism (codon 469) predisposes to sporadic AD, but a Finnish study failed to replicate this.

Purpose of the Study:

  • To investigate the association between the ICAM-1 E469K polymorphism and sporadic Alzheimer's disease in a Spanish population.
  • To determine if the ICAM-1 codon 469 polymorphism is a risk factor for Alzheimer's disease in this specific ethnic group.

Main Methods:

  • A case-control study was conducted.
  • 283 clinically defined sporadic Alzheimer's disease patients and 283 control subjects from Spain were recruited.
  • Genotype and allele frequencies of the ICAM-1 E469K polymorphism were compared between cases and controls.

Main Results:

  • No significant difference was observed in the E469K genotype frequencies between Alzheimer's disease patients and control subjects.
  • Allele frequencies of the ICAM-1 E469K polymorphism did not differ significantly between the patient and control groups.
  • The study found no association between the ICAM-1 E469K polymorphism and sporadic Alzheimer's disease in the Spanish population.

Conclusions:

  • The findings in the Spanish population do not support the hypothesis that the ICAM-1 E469K polymorphism is causally related to Alzheimer's disease.
  • This study adds to the conflicting evidence regarding the role of ICAM-1 polymorphisms in Alzheimer's disease susceptibility.
  • Further research may be needed to explore other genetic or environmental factors contributing to Alzheimer's disease.

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