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CD4+ effector T cell distribution in vivo: TGF-beta 1/TGF-beta receptor II interaction during activation mediates

Ulrike Bode1, Kerstin Tiedemann, Jürgen Westermann

  • 1Functional and Applied Anatomy, Medical School of Hannover, Hannover, Germany. Bode.Ulrike@MH-Hannover.de

European Journal of Immunology
|March 30, 2004
PubMed

CD4(+) effector T cells generated in mesenteric lymph nodes (mLN) leave into the blood. Although they enter many tissues, mLN effector T cells are later found preferentially in the gut,the drainage area of mLN. We show in the rat that this is not an intrinsic property of mLN T cells. Instead, within the mLN milieu T cells are instructed by cytokines such as transforming growth factor beta 1 (TGF-beta 1) to up-regulate TGF-beta receptor II (TGF-beta RII) during activation. This enables effector T cells to continue proliferation upon subsequent contact with TGF-beta 1 in mLN and gut, and to accumulate in the lymph node draining area, the most likely site of pathogen invasion.

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