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Down-modulation of lymphoproliferation and interferon-gamma production by beta-glucan derived from Saccharomyces
A C Pelizon1, R Kaneno, A M Soares
1Departamento de Microbiologia e Imunologia, Instituto de Biociências da Unesp, Faculdade de Medicina, Campus de Botucatu, 18618-000 Botucatu, SP, Brasil. acpelizon@bol.com.br
Abstract:
beta-glucan, one of the major cell wall components of Saccharomyces cerevisiae, has been found to enhance immune functions. This study investigated in vivo and in vitro effects of beta-glucan on lymphoproliferation and interferon-gamma (IFN-gamma) production by splenic cells from C57BL/6 female mice. All experiments were performed with particulate beta-glucan derived from S. cerevisiae. Data demonstrated that both, i.p. administration of particulate beta-glucan (20 or 100 micrograms/animal) and in vitro stimulation of splenic cells (20 or 100 micrograms/ml of culture) decreased lymphoproliferation and IFN-gamma production induced by concanavalin A. These results suggest that beta-glucan can trigger a down-modulatory effect regulating a deleterious immune system hyperactivity in the presence of a strong stimulus.

