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Related Experiment Videos

Sepsis in burned patients.

Jefferson Lessa de Macedo1, Simone C Rosa, Cleudson Castro

  • 1Hospital Regional da Asa Norte, Secretaria de Saúde do Distrito Federal, Brasília, DF. 2. Núcleo de Medicina Tropical da Universidade de Brasília, DF. glsmacedo@yahoo.com.br

Revista Da Sociedade Brasileira De Medicina Tropical
|March 31, 2004
PubMed
Summary

Sepsis affects nearly 20% of burn patients, with Staphylococcus aureus and Acinetobacter baumannii being common culprits. Early diagnosis and treatment are crucial for survival in these critical cases.

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Area of Science:

  • Infectious Diseases
  • Burn Care
  • Critical Care Medicine

Background:

  • Sepsis is a significant complication in burn patients, leading to increased morbidity and mortality.
  • Understanding the epidemiological and microbiological profile of sepsis in burn units is essential for effective management.

Purpose of the Study:

  • To prospectively investigate the incidence, clinical features, microbiological causes, and outcomes of sepsis in patients admitted to a burns unit.
  • To identify common pathogens, antibiotic resistance patterns, and risk factors associated with sepsis development post-burn.

Main Methods:

  • Prospective study conducted over 12 months in a hospital burns unit.
  • Inclusion of all patients treated at the unit, with detailed data collection on demographics, burn characteristics, sepsis episodes, and microbiological findings.

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  • Analysis of clinical and laboratory data, causative agents, antibiotic sensitivities, and patient outcomes, including mortality.

    • Main Results:

    • Sepsis developed in 19.4% of 252 burn patients, with a mean age of 22 years and a mean burn surface area of 37.7%.
    • Common pathogens included Staphylococcus aureus (including oxacillin-resistant strains), Acinetobacter baumannii, Enterobacter cloacae, and Klebsiella pneumoniae.
    • Mortality rate was 24.5%, with fever, dyspnea, and hypotension being common clinical signs; anemia and leukocytosis were frequent laboratory findings.

    Conclusions:

    • Sepsis is a frequent and serious complication in burn patients, often polymicrobial and associated with significant mortality.
    • Knowledge of local epidemiological and microbiological patterns, including antibiotic resistance, is vital for timely and appropriate sepsis management in burn care.
    • Prompt diagnosis and targeted treatment based on clinical, laboratory, and microbiological data can improve patient outcomes.