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[Risk factors associated with coagulation abnormalities in Bothrops envenoming]
Ricardo Borges de Oliveira1, Lindioneza Adriano Ribeiro, Miguel Tanús Jorge
1Faculdade de Medicina da Universidade Federal de Uberlândia, Depto de Clínica Médica, Av. Pará 1720, Campus Umuarama, 38400 902, Uberlândia, MG, Brasil.
Revista Da Sociedade Brasileira De Medicina Tropical
|March 31, 2004
Summary
Blood incoagulability in Bothrops envenoming is linked to several factors, including bite location and patient symptoms. However, this specific condition does not correlate with the overall clinical outcome of snakebite victims.
Area of Science:
- Herpetology
- Toxicology
- Clinical Medicine
Context:
- Bothrops envenoming is a significant public health concern, particularly in regions where these snakes are endemic.
- Understanding the factors influencing venom-induced coagulopathy is crucial for effective patient management.
Purpose:
- To identify clinical and epidemiological factors associated with blood incoagulability following Bothrops snakebites.
- To determine if blood incoagulability predicts the clinical outcome in envenomed patients.
Summary:
- A retrospective analysis of 2,991 patient records revealed factors positively associated with blood incoagulability, including seasonality, bite location, local and systemic symptoms, and antivenom administration details.
- Factors negatively associated included snake size, tourniquet use, and time to antivenom initiation.
- Importantly, blood incoagulability was not found to be associated with severe clinical outcomes such as amputation, renal failure, or death.
Impact:
- This study clarifies the predictors of coagulopathy in Bothrops envenoming, aiding in risk assessment.
- The findings highlight that while coagulopathy is an early indicator, it may not be a reliable predictor of long-term clinical sequelae.