[Verrucous carcinoma--histological and molecular analysis]

Carcinoma verrucosum is a histologic variant of a well differentiated squamous cell carcinoma, applied to 1-4% of all cases of laryngeal cancer. These lesions rarely cause deep invasion or metastasis to cervical lymph nodes and distant metastases. Among etiologic factors are smoking and purely oral hygiene. Last studies suggest HPV infection etiology in laryngeal cancer, mainly HPV 16 and and HPV 18. The aim of the study was to determine morphologic assessment of verruous carcinoma and the presence of HPV infection in patients suffered from verrucous carcinoma of laeynxd in the Department of Otolaryngology Medical Academy of Bialystok in years 2000-2002. The primers pU-1M/pU-2R were used to detect the high risk HPV which are HPV 16,18,31,33,35. The pair of pU-31B/pU-2R were used to detect low risk HPV which are HPV 6,11. In 2 cases (40%) HPV of high risk was determined. The histological assessment as well as molecular may play an important role in the clinical and diagnostic estimation in order to make a proper tumor classification and decide on the most effective treatment.