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Equipoise: beyond rehabilitation?

Jerry Menikoff¹

¹University of Kansas, Kansas City, USA.

Kennedy Institute of Ethics Journal

|March 31, 2004

Summary

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Charles Fried did not promote equipoise in clinical trials. His core argument emphasized patients' rights to informed consent and autonomous decision-making regarding trial participation.

Area of Science:

Bioethics
Clinical Trial Ethics
Research Ethics

Background:

Critiques Paul Miller and Charles Weijer's interpretation of Charles Fried's stance on equipoise.
Highlights a divergence from the conventional understanding of equipoise in research ethics.

Discussion:

Argues Fried's primary focus was patient autonomy and informed consent.
Contends Fried's work predates and challenges the modern definition of equipoise.
Emphasizes patient's right to self-determination in clinical trial participation.

Key Insights:

Charles Fried's concept of 'equipoise' was not an endorsement of the principle.
Patient rights to knowledge and decision-making are paramount in clinical trials.
Ethical considerations in clinical trials extend beyond equipoise.

Keywords:

Analytical Approach Biomedical and Behavioral Research

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Outlook:

Re-evaluates the historical context of ethical discussions in clinical research.
Promotes a patient-centered approach to clinical trial participation.
Encourages nuanced interpretations of foundational ethical principles in bioethics.