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Intravenous desensitization to allopurinol in a heart transplant patient with gout
Michael J Schumacher1, Jack G Copeland
1Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA. schumach@u.arizona.edu
Background:
Oral desensitization with allopurinol presents a problem for patients with allopurinol hypersensitivity and gout that needs to be controlled rapidly. To our knowledge, only 1 case report of intravenous (i.v.) desensitization has been previously published.
Objective:
To present a case report of a patient with cutaneous reactions to allopurinol who underwent i.v. allopurinol desensitization.
Methods:
Intravenous infusion of allopurinol was performed using an escalating, 19-dose protocol.
Results:
No adverse reactions were precipitated by 2 i.v., escalating dose procedures, allowing continuation of effective treatment of the patient's hyperuricemia.
Conclusions:
This case of safe and effective desensitization with allopurinol by the i.v. route should emphasize the need for a trial of this protocol in additional patients in whom rapid desensitization would be advantageous.
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