Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interplay between superantigens and immunoreceptors.

K Petersson1, G Forsberg, B Walse

  • 1Active Biotech Research AB, Lund, Sweden.

Scandinavian Journal of Immunology
|March 31, 2004
PubMed
Summary

Superantigens (SAGs) trigger massive T-cell activation by binding to MHC class II and TCRs. This review classifies SAG subclasses by their binding modes, aiding understanding of T-cell responses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of the New Nordic Diet compared with usual care on glucose control in gestational diabetes mellitus: Study protocol for the randomized controlled trial intervention with new Nordic DIet in women with GestatiOnal diabetes mellitus (iNDIGO).

Contemporary clinical trials·2022
Same author

Exploration of clinical preferences in treatment planning of radiotherapy for prostate cancer using Pareto fronts and clinical grading analysis.

Physics and imaging in radiation oncology·2021
Same author

Twenty-year follow-up of root filled teeth in a Swedish population receiving high-cost dental care.

International endodontic journal·2015
Same author

Formation of a hard tissue barrier after experimental pulp capping or partial pulpotomy in humans: an updated systematic review.

International endodontic journal·2015
Same author

Effect of education intervention on the quality and long-term outcomes of root canal treatment in general practice.

International endodontic journal·2014
Same author

Estimates of sensitivity and specificity of electric pulp testing depend on pulp disease spectrum: a modelling study.

International endodontic journal·2014

Area of Science:

  • Immunology
  • Microbiology
  • Molecular Biology

Background:

  • Superantigens (SAGs) are potent microbial toxins.
  • SAGs induce massive T-cell proliferation by cross-linking MHC class II and T-cell receptors (TCRs).
  • This interaction can lead to diseases like toxic shock syndrome.

Purpose of the Study:

  • To classify superantigens based on their distinct binding mechanisms to MHC class II.
  • To elucidate the structural basis of SAG-TCR interactions.
  • To understand the complexity of SAG-mediated T-cell activation.

Main Methods:

  • Review of existing literature on superantigen structure and function.
  • Classification of SAG subclasses according to MHC class II binding modes.
  • Description of trimolecular complex models (MHC-SAG-TCR).

Main Results:

  • SAGs exhibit diverse binding strategies to MHC class II, despite a conserved three-dimensional fold.
  • SAGs display specific preferences for TCR binding, interacting with variable beta-chains and potentially alpha-chains.
  • Classification reveals distinct subclasses based on MHC class II interaction modes.

Conclusions:

  • Understanding the varied binding modes of SAGs to MHC class II and TCRs is crucial.
  • Structural models of MHC-SAG-TCR complexes illuminate the mechanisms of T-cell activation.
  • This classification provides a framework for studying SAG-pathogenesis and T-cell responses.

Related Experiment Videos