Comparison of higher-order aberrations after LASEK with a 6.0 mm ablation zone and a 6.5 mm ablation zone with blend...

To compare the higher-order aberrations (HOAs) after laser-assisted subepithelial keratectomy (LASEK) using a conventional optical zone and a larger zone with a blend zone.

Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.

In this prospective study, 19 patients with a manifest refraction of -3.00 to -8.25 diopters (D) were treated with LASEK using a conventional (6.0 mm) optical zone in 1 eye and a larger (6.5 mm) zone with 8.0 mm blend zone in the other eye. The patients were followed for 3 months. Pupil size, best corrected visual acuity (BCVA), uncorrected visual acuity (UCVA), manifest refraction, corneal topography, pachymetry, and wavefront aberration were examined preoperatively; BCVA, UCVA, manifest refraction, and wavefront aberration were measured 1 and 3 months postoperatively. The Hartmann-Shack aberrometer (WaveScan(R), Visx) was used to measure the overall wavefront aberrations in scotopic pupils.

There were no significant differences in preoperative pupil size, BCVA, UCVA, and manifest refraction between the 2 groups or in postoperative BCVA, UCVA, and refraction. Higher-order aberrations increased at 1 and 3 months in both eyes compared with preoperatively. At 3 months, in a scotopic pupil, the mean root-mean-square wavefront error of the HOAs was 0.41 +/- 0.14 in the eyes treated with the larger optical zone and 0.61 +/- 0.28 in those treated with the conventional optical zone. There was a significant difference between optical zones (P =.006). The difference was more pronounced in the treatment of myopia greater than -5.0 D (P =.001).

In the scotopic condition, HOAs after LASEK using a large optical zone with blend zone ablation were smaller than those associated with conventional ablation zone treatment. The larger zone with blend zone treatment may be a good surgical alternative for better visual outcomes in scotopic conditions.