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Functional-anatomic correlates of remembering and knowing.

Mark E Wheeler1, Randy L Buckner

  • 1Department of Psychology, Washington University in St. Louis, St. Louis, MO 63130,USA. mw@npg.wustl.edu

Neuroimage
|March 31, 2004
PubMed
Summary

Remembering and knowing share brain processes for recognizing information. Remembering uniquely engages visual content regions, while knowing relies on general recognition signals. This reveals distinct neural pathways for memory recall.

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Area of Science:

  • Cognitive Neuroscience
  • Neuroimaging
  • Human Memory

Background:

  • The distinction between remembering (recollection) and knowing (familiarity) is crucial for understanding memory.
  • Previous neuroimaging studies have yielded mixed results regarding the neural correlates of remembering versus knowing.

Purpose of the Study:

  • To investigate the neural correlates of remembering and knowing using event-related functional magnetic resonance imaging (fMRI).
  • To explore the neural basis of conscious recollection versus familiarity in memory recognition.

Main Methods:

  • Employed a recognition paradigm with the remember/know (RK) procedure in 20 young adults.
  • Utilized event-related fMRI to capture neural activity during memory retrieval.
  • Paired studied items with pictures and sounds to enhance content retrieval.

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Main Results:

  • Remembering recruited regions associated with visual content processing and information oldness.
  • Knowing recruited regions associated with information oldness but not visual content.
  • Parietal cortex showed a dissociation: lateral regions for remembering, medial regions for both remembering and knowing.

Conclusions:

  • Both remembering and knowing involve common neural processes for recognizing information as old.
  • Remembering uniquely involves neural regions supporting retrieved content, contributing to vivid recollection.
  • Findings help reconcile divergent results in memory research by highlighting functional specializations within the parietal cortex.