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Contemporary paradigms for cholinergic ligand design guided by biological structure
Palmer Taylor1, Scott B Hansen, Todd T Talley
1Department of Pharmacology, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA. pwtaylor@ucsd.edu
Bioorganic & Medicinal Chemistry Letters
|March 31, 2004
Abstract:
The identification of the various nicotinic receptor subtypes, when coupled with the recent development of three-dimensional structures of surrogate extracellular receptor domains, offers new opportunities to design nicotinic ligands. Conformation and fluctuations in receptor structure are critical to ligand selectivity, and we present here how a flexible receptor template can be used in the development of selective ligands affecting cholinergic neurotransmission.