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Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity

Toshiyuki Kan1, Yusuke Tominari, Kentaro Rikimaru

  • 1Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Bioorganic & Medicinal Chemistry Letters
|March 31, 2004
PubMed

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Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
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