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The Australian Mohs database: periocular squamous cell carcinoma.
Raman Malhotra1, Shyamala C Huilgol, Nghi T Huynh
1Oculoplastic and Orbital Unit, Department of Ophthalmology, University of Adelaide, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia.
Ophthalmology
|March 31, 2004
Summary
Mohs micrographic surgery (MMS) for periocular squamous cell carcinoma (SCC) shows a low recurrence rate of 3.64% in this Australian study. Margin-controlled excision is crucial, especially for cases with perineural invasion (PNI), which had no recurrences.
Area of Science:
- Dermatology
- Oncology
- Surgical Pathology
Background:
- Periocular squamous cell carcinoma (SCC) presents unique surgical challenges.
- Mohs micrographic surgery (MMS) is a specialized technique for skin cancer removal.
- Data on MMS for periocular SCC in Australia is limited.
Purpose of the Study:
- To report outcomes of periocular SCC treated with MMS in Australia.
- To evaluate recurrence rates and prognostic factors.
- To highlight the efficacy of margin-controlled excision.
Main Methods:
- Prospective, noncomparative, multicenter, interventional case series.
- Seventy-nine patients with periocular SCC treated with MMS (1993-1999).
- Outcome measures included recurrence, tumor characteristics, and perineural invasion (PNI).
Main Results:
- Lower eyelid SCC was most common (68%), followed by medial canthus (24%).
- Well-differentiated (48.7%) and moderately differentiated (35.1%) SCC were prevalent.
- A 3.64% recurrence rate was observed with a median follow-up of 73 months.
Conclusions:
- MMS offers the lowest reported recurrence rate for periocular SCC.
- No recurrences were noted in cases with PNI, underscoring the value of MMS.
- This study represents the largest prospective series of MMS for periocular SCC in Australia.