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Aging and oxidative stress.

Virginia B C Junqueira1, Silvia B M Barros, Sandra S Chan

  • 1Departamento de Medicina, Centro de Estudos do Envelhecimento, Universidade Federal de São Paulo, 6 andar, Rua Pedro de Toledo 781, 04039032 Sao Paulo, Brazil. junqueira.dmed@epm.br

Molecular Aspects of Medicine
|March 31, 2004
PubMed
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Human aging is linked to increasing oxidative stress. This study measured key antioxidants and enzymes in 503 healthy individuals, finding a gradual development of oxidative stress with age.

Area of Science:

  • Gerontology
  • Biochemistry
  • Oxidative Stress Research

Background:

  • The relationship between aging and oxidative stress is a long-standing topic in scientific discourse.
  • While a definitive consensus is lacking, substantial data exists on aging processes and their connection to an organism's oxidant status.

Purpose of the Study:

  • To review key studies elucidating the aging-oxidative stress interplay.
  • To explain fundamental events and elusive causal relationships in aging and oxidative stress.
  • To present new data on the systemic oxidative stress status in healthy humans.

Main Methods:

  • Review of existing literature on aging and oxidative stress.
  • Analysis of plasma levels of TBARS (thiobarbituric acid reactive substances).

Related Experiment Videos

  • Measurement of nutritional antioxidants (alpha-tocopherol, beta-carotene, ascorbic acid) and antioxidant enzyme activities (Cu, Zn-superoxide dismutase, catalase, glutathione peroxidase) in red blood cells from 503 healthy subjects.

    • Main Results:

    • A moderate state of oxidative stress progressively emerges during human aging.
    • Data from 503 healthy individuals support the gradual development of oxidative stress with advancing age.
    • Specific biomarkers indicate a shift in oxidant-antioxidant balance over the lifespan.

    Conclusions:

    • The findings suggest a correlation between the aging process and a developing oxidative stress condition.
    • Further research is warranted to fully understand the complex causal relationships.
    • The study provides empirical evidence for age-related oxidative stress in humans.