Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sampling strategies for prospective studies of menstrual function.

Lynda Lisabeth1, Siobán D Harlow, Xihong Lin

  • 1Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.

American Journal of Epidemiology
|March 31, 2004
PubMed
Summary

Optimal menstrual study design involves following more women for shorter periods to assess exposures, or fewer women for longer periods to track reproductive lifespan changes. This ensures adequate statistical power.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Changes in Life Expectancy After Stroke Among Americans Aged 50 and Above by Sex, 1996-2018.

Journal of the American Geriatrics Society·2026
Same author

Factors Underlying Stroke Recovery Variation by Neighborhood Socioeconomic Status.

JAMA network open·2026
Same author

Joint modeling of multiple longitudinal biomarkers and survival outcomes via threshold regression: variability as a predictor.

Biometrics·2026
Same author

Sex differences in the prospective associations of long COVID with incident cardiometabolic and respiratory diseases from a population-based longitudinal study in Michigan.

Preventive medicine reports·2026
Same author

Per- and polyfluoroalkyl substances (PFAS) and menstrual cycle characteristics in midlife women: The Study of Women's Health Across the Nation.

Reproductive toxicology (Elmsford, N.Y.)·2026
Same author

Sex Differences in Young Adult Stroke Severity Using Linked Colorado-All Payer's Claims Database and the Get With The Guidelines-Stroke Registry.

Journal of the American Heart Association·2026

Area of Science:

  • Reproductive Epidemiology
  • Biostatistics
  • Women's Health Research

Background:

  • Optimal sampling strategies for prospective menstrual function studies are not well-defined.
  • Current menstrual studies often prioritize feasibility over statistical principles for sample size and duration.
  • Sample size estimates frequently overlook the longitudinal nature of menstrual cycle data.

Purpose of the Study:

  • To determine optimal sampling strategies for prospective menstrual studies.
  • To evaluate methods for assessing differences in mean cycle length between exposure groups.
  • To assess changes in mean cycle length across the reproductive lifespan.

Main Methods:

  • Utilized data from the Tremin Trust study (1935-1977).
  • Analyzed data to determine optimal sample size and duration for different study objectives.

Related Experiment Videos

  • Applied statistical principles to assess menstrual cycle length variations.

    • Main Results:

    • Following a larger cohort of women for 1-2 years is optimal for studying environmental or host exposures affecting menstrual function.
    • Following a smaller cohort for 4-5 years is optimal for examining menstrual pattern variations across the reproductive lifespan.
    • Statistical power is enhanced by aligning study duration and participant numbers with specific research questions.

    Conclusions:

    • Study design for menstrual function research should be tailored to specific objectives.
    • Prospective studies investigating exposures benefit from larger, shorter-term cohorts.
    • Longitudinal studies examining lifespan changes benefit from smaller, longer-term cohorts.