Related Experiment Video
Updated: Aug 16, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
Published on: February 13, 2018
Hydrogen sulphide: an endogenous stimulant of capsaicin-sensitive primary afferent neurons?
1School of Biomedical Sciences, University of Newcastle, NSW 2308, Australia. loris.chahl@newcastle.edu.au
Abstract:
Hydrogen sulphide (H(2)S) is a gas best known for its rotten egg smell. The toxic effects of high concentrations of H(2)S have been extensively investigated. It is known that H(2)S is generated in mammalian systems, but little is known of its effects in physiological concentrations. In the present issue of this journal, Patacchini et al. present evidence that H(2)S stimulates capsaicin-sensitive primary afferent neurons to release tachykinins in the rat urinary bladder. The possible significance of this finding is discussed in this commentary.
Related Concept Videos
Thermosensation
Mechanically-gated Ion Channels
Sensory Functions of the Skin
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
Integration of Synaptic Events
Pain

