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Amyloid myopathy presenting with distal atrophic weakness
Cathrine Smestad1, Per Monstad, Christian Fredrik Lindboe
1Department of Neurology, Sørlandet Sykehus Kristiansand, Serviceboks 416, N-4604 Kristiansand, Norway. cathrinesmestad@hotmail.com
Muscle & Nerve
|March 31, 2004
Summary
Amyloid myopathy, a rare complication of primary amyloidosis, can manifest as finger muscle weakness in multiple myeloma patients. Early recognition is crucial as symptoms may improve with chemotherapy.
Area of Science:
- Neurology
- Hematology
- Pathology
Background:
- Amyloid myopathy is an uncommon manifestation of primary amyloidosis.
- It typically presents with proximal muscle weakness.
Observation:
- This report details a multiple myeloma case where finger flexor muscle atrophy and weakness were initial signs of systemic amyloidosis.
- Muscle biopsy confirmed amyloid angiopathy.
Findings:
- Amyloid deposits, specifically lambda light chains, were identified in the vessel walls.
- This indicates a specific type of amyloidosis linked to multiple myeloma.
Implications:
- Recognizing amyloid myopathy is vital for timely diagnosis and treatment.
- Chemotherapy may effectively manage the clinical symptoms of amyloid myopathy.