Related Experiment Video
Updated: Aug 25, 2026
Establishing a Three-Dimensional Coculture Module of Epithelial Cells Using Nanofibrous Membranes
Published on: December 27, 2024
[Structure and degradation property of the PVA-collagen complex drug membrane]
Yi Liang1, Ling-rong Liu, Qi-qing Zhang
1Biomaterials Lab, Institute of Biomedical Engineering, CAMS and PUMC, Tianjin 300192, China.
Objective:
To investigate the structure and degradation property of the polyvinyl alcohol (PVA)-collagen complex drug membrane.
Methods:
Drug collagen membrane was complexed with PVA. The physical and chemical properties of the membrane were characterized by transmission electron microscopy, scanning electron microscope, forier transform-infrared spectroscopy and differential scanning calorimetry. Degradation experiment was performed to determine the degradation property of membrane and a degradation curve was therefor drawn.
Results:
The thermodynamic stability of collagen membrane was not destroyed by adding PVA. Collagen had good compatibility with PVA. Compared with collagen membrane, collagen-PVA complex membrane had smaller and evener pores. Adding PVA decreased the degradation rate of membrane.
Conclusions:
PVA-collagen membrane has better microstructure and antidegradation property than collagen membrane.
