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Related Experiment Videos

[Brain volumetric MRI study in healthy elderly persons using statistical parametric mapping].

Yoshinao Miyahira1, Jin Yu, Ken-Ichi Hiramatsu

  • 1Department of Neuropsychiatry, Faculty of Medicine, University of the Ryukyus.

Seishin Shinkeigaku Zasshi = Psychiatria Et Neurologia Japonica
|April 1, 2004
PubMed
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Brain volume naturally decreases with age in healthy elderly individuals. Specific regions like the prefrontal cortex and entorhinal cortex showed the most significant age-related volume reduction.

Area of Science:

  • Neuroimaging
  • Gerontology
  • Brain Anatomy

Background:

  • Aging is associated with structural brain changes.
  • Understanding these changes in healthy elderly individuals is crucial for differentiating normal aging from disease.
  • Volumetric Magnetic Resonance Imaging (MRI) provides quantitative measures of brain structures.

Purpose of the Study:

  • To investigate age-related volumetric changes in specific brain regions of healthy elderly subjects.
  • To compare the rate of volume reduction across different brain areas, including the whole brain, gray matter, prefrontal cortex, hippocampus, and entorhinal cortex.

Main Methods:

  • Volumetric MRI was performed on 61 healthy elderly subjects (aged 61-91).
  • Statistical Parametric Mapping (SPM) and Region of Interest (ROI) methods were used for volumetric analysis.

Related Experiment Videos

  • Data were analyzed for correlations between age and the volumes of the whole brain, gray matter, prefrontal cortex, hippocampus, and entorhinal cortex.

    • Main Results:

    • Significant age-related volume reductions were observed in the whole brain, gray matter, prefrontal cortex, hippocampus, and entorhinal cortex.
    • The prefrontal cortex and entorhinal cortex exhibited greater age-related volume reduction compared to the overall gray matter.
    • Sex differences were noted in prefrontal cortex and hippocampal volumes, with females having larger volumes. Hippocampal and entorhinal cortex volumes showed lateralization.

    Conclusions:

    • Age-related brain atrophy is not uniform across all brain regions.
    • The prefrontal cortex and entorhinal cortex are particularly vulnerable to age-related volume loss.
    • Findings highlight regional differences in brain aging, with implications for understanding cognitive decline in aging populations.