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Published on: March 9, 2018

Clinical manifestations and treatment outcomes of pulmonary aspergilloma

Sang Hoon Lee1, Byoung Jun Lee, Do Young Jung

  • 1Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.

The Korean Journal of Internal Medicine
|April 1, 2004
PubMed
Abstract

Insights

Pulmonary aspergilloma, often linked to lung disease, requires careful surgical candidate selection. This study analyzed 36 cases, highlighting hemoptysis as a key symptom and tuberculosis as a common underlying condition.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Medical Mycology

Background:

  • Pulmonary aspergilloma arises from Aspergillus colonization in damaged lungs or pre-existing lung conditions.
  • This retrospective study examines 36 patients diagnosed with pulmonary aspergilloma.

Purpose of the Study:

  • To analyze the clinical characteristics of pulmonary aspergilloma.
  • To evaluate diagnostic methods and management strategies for pulmonary aspergilloma.
  • To identify factors influencing outcomes in pulmonary aspergilloma patients.

Main Methods:

  • Retrospective review of medical records for 36 pulmonary aspergilloma patients (1988-2000).
  • Analysis of clinical features, symptoms (hemoptysis), and underlying lung diseases (pulmonary tuberculosis).
  • Evaluation of diagnostic tools including chest CT and precipitin antibody tests.

Main Results:

  • The median age was 53.3 years, with a male predominance (2.36:1).
  • Hemoptysis occurred in 65% of patients; pulmonary tuberculosis was the most common underlying disease (81%).
  • Surgical resection was performed in 20 patients, with a 5.6% post-operative mortality rate and complications in 7 cases.

Conclusions:

  • Pulmonary aspergilloma predominantly affects patients with underlying lung diseases.
  • Surgical resection is the primary treatment but carries significant risks.
  • Developing clear criteria for surgical candidate selection is crucial to minimize complications and mortality.

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