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Agranulocytosis induced by vancomycin in an ESRD patient on CAPD
Young-Il Jo1, Jae-Ho Yoon, Sang-Youl Shin
1Division of Nephrology, Department of Internal Medicine, Konkuk University College of Medicine, Seoul, Korea.
Abstract:
Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients. We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia. The agranulocytosis was rapidly resolved by granulocyte colony-stimulating factor (G-CSF) therapy and by the discontinuation of vancomycin.
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