Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reading tarot cards.

L Henry Edmunds1

  • 1University of Pennsylvania School of Medicine, Philadelphia, PA, USA. hank.edmunds@uphs.upenn.edu

The Surgical Clinics of North America
|April 1, 2004
PubMed
Summary
This summary is machine-generated.

Acute myocardial infarction can cause progressive heart failure. Early surgical intervention before adverse cardiac remodeling may prevent myocyte apoptosis and improve survival in heart failure patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Benson Bertheau Roe, Md, July 7, 1918-August 6, 2012.

The Annals of thoracic surgery·2013
Same author

Managing fibrinolysis without aprotinin.

The Annals of thoracic surgery·2010
Same author

Thrombin during cardiopulmonary bypass.

The Annals of thoracic surgery·2006
Same author

Truncated and microparticle-free soluble tissue factor bound to peripheral monocytes preferentially activate factor VII.

Thrombosis and haemostasis·2006
Same author

Plasma tissue factor plus activated peripheral mononuclear cells activate factors VII and X in cardiac surgical wounds.

Journal of the American College of Cardiology·2005
Same author

Prevention of ischemic mitral regurgitation does not influence the outcome of remodeling after posterolateral myocardial infarction.

Journal of the American College of Cardiology·2004
Same journal

Stepwise Solutions-Society.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions-Hospitals.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions for Providers.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions-Patients Social Determinants of Health, Health Disparities, and Surgical Equity.

The Surgical clinics of North America·2026
Same journal

Post Hospital Surgical Disparities.

The Surgical clinics of North America·2026
Same journal

Inhospital Surgical Disparities.

The Surgical clinics of North America·2026
See all related articles

Area of Science:

  • Cardiovascular Medicine
  • Cardiac Surgery
  • Pathophysiology

Background:

  • Acute myocardial infarction can lead to progressive left ventricular dilatation, heart failure, and death.
  • Post-infarction heart failure has a high 5-year mortality rate of 50%.
  • Myocardial stretching initiates a myopathic process, causing myocyte apoptosis and adverse cardiac remodeling.

Purpose of the Study:

  • To investigate the mechanisms of adverse post-infarction remodeling.
  • To evaluate the efficacy of current treatments for heart failure.
  • To propose an optimized surgical timing for heart failure management.

Main Methods:

  • Review of pathophysiological processes following acute myocardial infarction.
  • Analysis of the impact of revascularization on myocardial contractility.

Related Experiment Videos

  • Evaluation of contemporary heart failure operations and their limitations.

    • Main Results:

    • Revascularization restores contractility in stunned/hibernating myocardium but not in myopathic, remodeling myocardium.
    • Current heart failure surgeries temporarily reduce wall stress but do not reverse myocyte apoptosis.
    • Myocyte apoptosis induced by stretch may be irreversible.

    Conclusions:

    • Preventing the myopathic process after acute infarction is crucial for extending survival.
    • Surgical intervention should occur before adverse post-infarction left ventricular remodeling.
    • New surgical approaches are needed to address stretch-induced myocyte apoptosis proactively.