Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fundus pigmentation and the dark-adapted electroretinogram.

N Wali1, L E Leguire

  • 1Department of Ophthalmology, Columbus Children's Hospital, Ohio.

Documenta Ophthalmologica. Advances in Ophthalmology
|January 1, 1992
PubMed
Summary

Fundus pigmentation impacts electroretinogram (ERG) b-wave amplitudes, with lighter fundi showing larger responses. This finding is crucial for interpreting ERG data accurately.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infectivity and pathobiology of H7N1 and H5N8 high pathogenicity avian influenza viruses for pigeons (<i>Columba livia var. domestica</i>).

Avian pathology : journal of the W.V.P.A·2020
Same author

Experimental infection of domestic geese (<i>Anser anser var. domesticus</i>) with H5N8 Gs/GD and H7N1 highly pathogenic avian influenza viruses.

Avian pathology : journal of the W.V.P.A·2020
Same author

Relationship among fMRI, contrast sensitivity and visual acuity.

Brain research·2010
Same author

Development of two stable oral suspensions of levodopa-carbidopa for children with amblyopia.

Journal of pediatric ophthalmology and strabismus·2001
Same author

Occlusion and levodopa-carbidopa treatment for childhood amblyopia.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus·2000
Same author

Levodopa-carbidopa and childhood retinal disease.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus·1999

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Physiology

Background:

  • The electroretinogram (ERG) measures retinal function.
  • Fundus pigmentation is known to influence retinal physiology.
  • Variability in ERG responses necessitates understanding contributing factors.

Purpose of the Study:

  • To investigate the relationship between fundus pigmentation and dark-adapted electroretinogram (ERG) b-wave amplitudes in normal subjects.
  • To determine if fundus pigmentation affects key parameters of the luminance-response function, such as Vmax, log K, and n.
  • To assess the influence of fundus pigmentation on b-wave implicit times.

Main Methods:

  • Dark-adapted electroretinograms were recorded from 32 normal subjects (17 black, 15 white) across a 3.6-log unit range of stimulus intensities.
  • Subjects were categorized into light and dark fundus pigmentation groups based on digitized fundus photographs.
  • Naka-Rushton equation was used to fit b-wave amplitude versus luminance data, yielding Vmax, log K, and n parameters.

Main Results:

  • Subjects with lighter fundi exhibited significantly larger b-wave amplitudes across all luminance levels compared to those with darker fundi.
  • A significant difference was observed between the groups for Vmax (maximal b-wave response) and n (Hill coefficient), but not for log K (semi-saturation constant).
  • No significant differences in b-wave implicit times were found between light and dark fundus pigmentation groups.

Conclusions:

  • Fundus pigmentation is a significant factor influencing the amplitude of the dark-adapted ERG b-wave, specifically affecting Vmax and the steepness of the response function.
  • These findings have important implications for establishing normative ERG data and for the clinical interpretation of ERG results, particularly in diverse populations.
  • The observed relationship between Vmax and fundus pigmentation was independent of age, gender, refractive error, axial length, and intraocular pressure.

Related Experiment Videos