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The chirality of a four-way helical junction in RNA
Terry A Goody1, David M J Lilley, David G Norman
1Cancer Research UK Nucleic Acid Structure Research Group, MSI/WTB Complex, The University of Dundee, Dundee DD1 5EH, UK.
Journal of the American Chemical Society
|April 1, 2004
Abstract:
We have used a novel electrophoretic approach to determine the chirality of a four-way helical junction in RNA. From our experiments we conclude that the handedness of the helical junction in the complete ribozyme is opposite to that found in the free junction and is therefore constrained by the interaction between the unpaired loops of the ribozyme.
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