Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary amyloidosis presenting as small bowel encapsulation.

Jennifer Jones1, Guido VanRosendaal, Cynthia Cleary

  • 1Department of Medicine, Division of Gastroenterology, Dalhousie University, Halifax, Nova Scotia. joneskenyon@yahoo.ca

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
|April 1, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selecting, Scaling, and Measuring the Value of Ambient AI in a Nonacademic Health System: Multiphase Pilot Study.

JMIR medical informatics·2026
Same author

Extracellular Vesicles from Glioblastoma Cells Reflect 2D vs. 3D Culture Adaptation and Resistance to Temozolomide.

Molecular & cellular proteomics : MCP·2026
Same author

Interventions to Improve Clinician Implementation of and Patient Adherence to Recommendations on Geriatric Assessment and Management: A Scoping Review.

Journal of the American Geriatrics Society·2026
Same author

Positive and Adverse Childhood Experiences and Adult Health and Economic Outcomes.

Pediatrics·2026
Same author

Recent Trends in Clinical Trials for Pediatric Sarcoma in the United States: An Analysis of ClinicalTrials.gov.

Children (Basel, Switzerland)·2026
Same author

A Sedentary Behaviour Reduction Programme in Patients With Peripheral Arterial Disease: A Mixed-Method Feasibility Study.

International journal of vascular medicine·2026

This case report details a rare instance of primary amyloidosis causing small bowel obstruction via encapsulating peritonitis. It highlights the diagnostic challenges and unique presentation of amyloidosis.

Area of Science:

  • Gastroenterology
  • Nephrology
  • Oncology

Background:

  • Amyloidosis involves extracellular deposition of fibrillar proteins, leading to diverse clinical presentations based on organ involvement.
  • Primary amyloidosis, often associated with plasma cell dyscrasias, typically affects organs like the kidneys, heart, and nerves.

Observation:

  • A 62-year-old man presented with small bowel obstruction due to a unique membrane encasing the small bowel, diagnosed as encapsulating peritonitis due to amyloidosis.
  • Initial biopsies were inconclusive, but duodenal biopsies confirmed primary amyloidosis, with subsequent development of nephrotic syndrome and renal amyloidosis.

Findings:

  • Histopathology revealed Congo red-positive, apple-green birefringent material consistent with amyloid deposition.
  • The patient had a monoclonal paraprotein (Immunoglobulin G lambda) and mild bone marrow plasmacytosis, indicative of an underlying plasma cell disorder.

Related Experiment Videos

  • Despite initial asymptomatic recovery, progressive renal involvement necessitated high-dose chemotherapy and autologous stem cell transplant.

    • Implications:

    • This case represents the first documented instance of primary amyloidosis presenting as small bowel obstruction secondary to encapsulating peritonitis.
    • It underscores the importance of considering amyloidosis in unexplained gastrointestinal obstructions, even with atypical presentations.
    • The case highlights the potential for multi-organ involvement in primary amyloidosis and the need for comprehensive diagnostic workups.