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Published on: October 22, 2013
Does whipworm increase the pathogenicity of Campylobacter jejuni? A clinical correlate of an experimental observation
Jennifer L Shin1, Geoffrey W Gardiner, Wayne Deitel
1Department of Internal Medicine, Division of Gastroenterology, St Michael's Hospital, University of Toronto, Toronto, Ontario.
Abstract:
Campylobacter jejuni is a leading cause of acute diarrhea worldwide, usually mild and self-limiting. No adequate hypothesis has yet been formulated to explain why in an otherwise healthy host this infection is occasionally severe. In a pig model, C jejuni has been shown to be pathogenic only in the presence of swine whipworm. A human case of life-threatening C jejuni colitis leading to toxic megacolon and acute renal failure, associated with concomitant whipworm (Trichuris suis) ova in the feces, is reported. The potential of T suis to potentiate C jejuni in humans deserves further study.
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