Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Colorectal polyposis and immune-based therapies.

Pearl Jacobson-Brown1, Manuela G Neuman

  • 1In Vitro Toxicology Laboratory, Kunin-Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Toronto, Ontario.

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
|April 1, 2004
PubMed
Summary

Colorectal cancer progression involves immune responses and cytokines. New therapies like gene therapy and immunotherapy offer promising treatments for colon polyps and cancer.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Herbal Remedies in Global Health Care: Classification, Toxicology, and Clinical Management.

Therapeutic drug monitoring·2025
Same author

Phytotherapy-Induced Hepatocytotoxicity: A Case Report.

Current issues in molecular biology·2024
Same author

Pathogenesis of Alcoholic Fatty Liver a Narrative Review.

Life (Basel, Switzerland)·2023
Same author

Fatty Liver Disease-Alcoholic and Non-Alcoholic: Similar but Different.

International journal of molecular sciences·2022
Same author

Molecular, Viral and Clinical Features of Alcohol- and Non-Alcohol-Induced Liver Injury.

Current issues in molecular biology·2022
Same author

Alcohol: basic and translational research; 15th annual Charles Lieber &1st Samuel French satellite symposium.

Experimental and molecular pathology·2022

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • Colorectal cancer (CRC) develops from precancerous colon polyps through complex immune interactions.
  • Cytokines significantly influence T cell activity, cell adhesion, apoptosis, and host immunity during CRC progression.

Purpose of the Study:

  • To review the immunological mechanisms driving colon tumor progression.
  • To discuss emerging molecular and immune-based therapies for colorectal neoplasia.

Main Methods:

  • Review of existing literature on immunology and colorectal cancer.
  • Analysis of current and experimental therapeutic strategies.

Main Results:

  • Cytokines play a critical role in the transition from adenoma to carcinoma.

Related Experiment Videos

  • Novel immunotherapies, including gene therapy and antibody-cytokine fusion proteins, are under investigation.
  • Anti-tumor necrosis factor antibodies show potential as chemoprotective agents.

    • Conclusions:

    • Understanding immune mechanisms is key to developing effective CRC treatments.
    • Adjuvant immunotherapies and targeted molecular therapies represent the future of CRC management.
    • Further research into immune-based strategies may improve prognosis and treatment outcomes.