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Odontogenic ghost cell carcinoma.

David Goldenberg1, James Sciubba, Ralph P Tufano

  • 1Department of Otolaryngology--Head and Neck Surgery, The Johns Hopkins University School of Medicine, JHOC, 601 N. Caroline St., Baltimore, Maryland, USA.

Head & Neck
|April 1, 2004
PubMed
Summary
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Odontogenic ghost cell carcinoma (OGCC) is a rare malignancy. Wide local excision with clear margins is the recommended treatment for OGCC, a malignant counterpart of calcifying odontogenic cyst (COC).

Area of Science:

  • Oral and Maxillofacial Surgery
  • Surgical Pathology
  • Oncology

Background:

  • Odontogenic ghost cell carcinoma (OGCC) is an exceptionally rare malignancy, representing the malignant form of calcifying odontogenic cyst (COC).
  • Historically, OGCC diagnosis relied on identifying malignant histological features alongside benign COC or its solid variant.

Observation:

  • A case report details a young Asian male with a recurring maxillary COC who developed a rapidly growing, painful swelling post-excision.
  • The patient underwent a subtotal maxillectomy for a 5-cm tumor invading the maxillary sinus and nasal cavity.

Findings:

  • Histopathological examination confirmed the tumor as OGCC.
  • Surgical excision achieved clear margins, and no adjuvant radiotherapy was administered.
  • The patient remained disease-free for 18 months post-surgery.

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Implications:

  • OGCC exhibits a spectrum of behavior, from locally invasive to highly aggressive.
  • Wide local excision with clear margins is the primary treatment strategy.
  • Long-term surveillance is crucial for recurrent or long-standing COCs and OGCCs.