Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyaluronan and morphogenesis.

Andrew P Spicer1, Janet Y L Tien

  • 1Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, Texas, USA. andrewp_spicer@hotmail.com

Birth Defects Research. Part C, Embryo Today : Reviews
|April 1, 2004
PubMed
Summary

Hyaluronan, a complex carbohydrate polymer, is crucial for vertebrate development and morphogenetic processes. Recent research has identified its key roles and molecular players, advancing our understanding of this extracellular matrix component.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hyaluronan synthesis induces microvillus-like cell surface protrusions.

The Journal of biological chemistry·2006
Same author

Plasma membrane residence of hyaluronan synthase is coupled to its enzymatic activity.

The Journal of biological chemistry·2005
Same author

Natural antisense mRNAs to hyaluronan synthase 2 inhibit hyaluronan biosynthesis and cell proliferation.

The Journal of biological chemistry·2005
Same author

The role of hyaluronan synthase 3 in ventilator-induced lung injury.

American journal of respiratory and critical care medicine·2005
Same author

Three vertebrate hyaluronan synthases are expressed during mouse development in distinct spatial and temporal patterns.

Developmental dynamics : an official publication of the American Association of Anatomists·2005
Same author

Expression of interleukin-17B in mouse embryonic limb buds and regulation by BMP-7 and bFGF.

Biochemical and biophysical research communications·2004

Area of Science:

  • Biochemistry
  • Developmental Biology
  • Extracellular Matrix Biology

Background:

  • Hyaluronan (HA) was previously viewed as a simple space-filling molecule in the extracellular matrix.
  • Recent research highlights HA's complex functional roles in biological processes.
  • HA is a unique carbohydrate polymer found in many extracellular matrices.

Purpose of the Study:

  • To review recent advances in understanding hyaluronan's biosynthesis, turnover, and binding proteins.
  • To elucidate hyaluronan's role in morphogenetic processes during vertebrate development.
  • To provide insight into how hyaluronan regulates vertebrate development.

Main Methods:

  • Molecular identification and cloning of hyaluronan synthases, hyaluronidases, and hyaladherins.

Related Experiment Videos

  • Gene targeting strategies to create knockout mice deficient in specific hyaluronan-related gene products.
  • Review of recent literature on hyaluronan's biological functions and developmental roles.

    • Main Results:

    • Significant progress has been made in identifying and characterizing the molecular components involved in hyaluronan metabolism and function.
    • Genetic inactivation of hyaluronan-related genes in mice has provided insights into their in vivo functions.
    • Hyaluronan is implicated in essential vertebrate developmental processes, including neural crest formation, skeletal development, and organogenesis.

    Conclusions:

    • Hyaluronan is a critical regulator of vertebrate development, essential for the formation and function of various tissues and structures.
    • Advances in molecular biology and genetic models have greatly expanded our understanding of hyaluronan's multifaceted roles.
    • Further research into hyaluronan's functions promises to uncover new therapeutic targets for developmental disorders.