Related Experiment Video
Updated: Aug 11, 2026
08:25
Evaluating the Function of the Foot Core System in the Elderly
Published on: March 11, 2022
[Osteopathy in diabetic foot syndrome]
I I Dedov1, P V Iushkov, A Iu Tokmakova
1Endocrinological Research Centre, 117036, Moscow.
Arkhiv Patologii
|April 2, 2004
Summary
Bone tissue differences in the feet of patients with type 1 (DM1) and type 2 (DM2) diabetes were identified. DM1 shows specific bone cell activity and collagen presence, while DM2 exhibits distinct bone cell types and tissue composition, suggesting varied osteolysis.
Area of Science:
- Bone biology
- Diabetology
- Tissue engineering
Context:
- Diabetes mellitus (DM) significantly impacts bone health, leading to increased fracture risk.
- Understanding the distinct morphological bone tissue characteristics in type 1 diabetes (DM1) and type 2 diabetes (DM2) is crucial for targeted interventions.
- Previous research has highlighted systemic effects of diabetes on bone metabolism, but specific foot bone tissue alterations remain less understood.
Purpose:
- To investigate and compare the morphological characteristics of bone tissue in the feet of patients with DM1 and DM2.
- To identify specific cellular and matrix differences in newly formed bone between DM1 and DM2.
- To analyze and differentiate the mechanisms of bone tissue resorption (osteolysis) in both diabetes types.
Summary:
- Morphological analysis of foot bone tissue revealed distinct features in DM1 and DM2.
- DM1 is characterized by osteoblasts and osteoclasts prevalence and collagen type III in newly formed bone.
- DM2 exhibits osteocytes prevalence and abundant granulation tissue, with periosteocytic osteolysis and smooth resorption being typical, unlike the lacunar osteoclastic resorption in DM1.
Impact:
- The findings suggest potentially different pathways for osteolysis genesis and bone tissue synthesis in DM1 and DM2.
- This research provides a foundation for developing specialized treatments for diabetic foot complications.
- Understanding these distinct bone tissue responses can inform strategies to mitigate bone fragility and improve healing in diabetic patients.
More Related Videos
04:09Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
05:06Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy
Published on: July 14, 2023
Related Concept Videos
01:20Pathophysiology of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
01:22Complications of Diabetes Mellitus
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
01:22Diabetic Ketoacidosis ll: Pathophysiology
Diabetic ketoacidosis (DKA) is a metabolic emergency characterized by hyperglycemia, ketonemia, and metabolic acidosis. It results from severe insulin deficiency and an excess of counterregulatory hormones, leading to uncontrolled lipolysis, ketogenesis, and widespread electrolyte and fluid disturbances.Pathophysiology The central event in DKA is a profound loss of insulin action. Without insulin, glucose uptake in insulin-dependent tissues is impaired, while hepatic glucose production...
01:31Diabetic Foot Ulcer
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:22Diabetic Neuropathy
DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...