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NERD: a DNA processing-related domain present in the anthrax virulence plasmid, pXO1
1Program in Bioinformatics and Systems Biology, The Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Trends in Biochemical Sciences
|April 2, 2004
Abstract:
We have identified a new domain in a broad range of bacterial, as well as single archaeal and plant proteins. Its presence in the virulence-related pXO1 plasmid of Bacillus anthracis as well as in several other pathogens makes it a possible drug target. We term the new domain nuclease-related domain (NERD) because of its distant similarity to endonucleases.