Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Formaldehyde scavenging from peritoneal dialysis solutions using reduced aminothiol compounds.

Stephen D Bird1, Michael Legge, Robert J Walker

  • 1Department of Medical and Surgical Sciences, University of Otago Medical School, Dunedin, New Zealand. sdbird@hotmail.com

Nephrology (Carlton, Vic.)
|April 2, 2004
PubMed
Summary

Aminothiol compounds effectively scavenge harmful aldehydes from solutions used in peritoneal dialysis (PD) and cryopreservation. This process forms stable compounds with antioxidant properties, potentially improving solution biocompatibility.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Urinary proteomic profiling to identify early biomarkers of non-diabetic chronic kidney disease.

Clinical kidney journal·2025
Same author

Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapy.

Intensive care medicine·2025
Same author

An unusual case of Herbaspirillum huttiense bacteraemia in a haemodialysis patient.

Nephrology (Carlton, Vic.)·2024
Same author

Autosomal dominant hypercalciuric hypocalcaemia: the calcium-sensing receptor in renal calcium homeostasis and the impact of renal transplantation.

Internal medicine journal·2024
Same author

The impact of peritoneal dialysis on oxypurinol and urate elimination in people with gout.

Nephrology (Carlton, Vic.)·2024
Same author

FTO-mediated m6A mRNA demethylation aggravates renal fibrosis by targeting RUNX1 and further enhancing PI3K/AKT pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2024

Area of Science:

  • Biochemistry
  • Materials Science
  • Medical Chemistry

Background:

  • Aldehydes are present in clinical solutions like peritoneal dialysis (PD) and cryoprotection solutions.
  • Aldehydes can cause cellular injury and peritoneal membrane damage in PD patients.
  • Aminothiol compounds can scavenge aldehydes, but the process and products were uncharacterized.

Purpose of the Study:

  • To investigate the kinetics and products of formaldehyde scavenging from artificial PD solutions using aminothiol compounds.
  • To characterize the reaction products formed during aldehyde scavenging.
  • To assess the potential of aminothiol compounds to improve PD solution biocompatibility.

Main Methods:

  • Proton nuclear magnetic resonance (NMR) spectroscopy was employed.

Related Experiment Videos

  • Formaldehyde scavenging was studied in artificial PD solutions with cysteamine or l-cysteine.
  • The reaction mechanism involved a two-step process forming stable thiazolidine compounds.

    • Main Results:

    • Formaldehyde scavenging proceeded in two steps: an intermediate formation followed by stable thiazolidine derivatives.
    • Cysteamine formed thiazolidine, and l-cysteine formed thiazolidine-4-carboxylic acid.
    • The scavenging process masked the destructive carbonyl group of formaldehyde.

    Conclusions:

    • Aminothiol compounds effectively scavenge formaldehyde, forming stable, potentially antioxidant compounds.
    • The addition of aminothiol compounds may enhance the biocompatibility of commercial PD solutions.
    • This scavenging mechanism offers a potential strategy to mitigate aldehyde-induced cellular damage.