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Updated: Aug 15, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
[Heart failure: etiology and approach to diagnosis]
Javier Segovia Cubero1, Luis Alonso-Pulpón Rivera, Roberto Peraira Moral
1Unidad de Insuficiencia Cardíaca y Trasplante Cardíaco, Clínica Puerta de Hierro, Madrid, Spain. jsecu@eresmas.net
Abstract:
In spite of its high prevalence and the huge burden it imposes on health care systems, heart failure is a clinical syndrome that has not yet been defined satisfactorily. In actual practice, diagnosis requires the presence of typical signs and symptoms along with data from complementary tests that indicate definite cardiac dysfunction. In this article we review current concepts of the disease, stages of development, common underlying causes, and the value of different diagnostic tests. Among these tests, measurement of B-type natriuretic peptide has proved useful for population screening and the differential diagnosis of heart failure. This indicator seems to be the ideal link between the large population of patients in whom heart failure is suspected and the subgroup for whom cardiac ultrasound, the most informative test in this disease, is warranted.
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