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Published on: February 21, 2018
Effect of a paraneoplastic cerebellar degeneration-associated neural protein on B-myb promoter activity
Koichiro Sakai1, Yoko Kitagawa, Shinji Saiki
1Department of Neurology, Kanazawa Medical University, Kahoku-gun, 920-0293 Ishikawa, Japan. ksakai@kanazawa-med.ac.jp
Abstract:
In this study, we have shown that a paraneoplastic cerebellar degeneration (PCD)-associated antigen, pcd17, binds to a cell cycle-related protein, MRG15. MRG15 derepresses the E2F-responsive B-myb promoter. The pcd17 antigen inhibits the derepression of the B-myb transcriptional activity by MRG15, and, as a result, pcd17 represses the promoter. Delivery of anti-Purkinje cell antibodies (anti-Yo) into the cells inhibits the repression of B-myb promoter activity by pcd17. Because derepression of the B-myb promoter has been implicated in neuronal death, the results suggest the possible role of the antibodies in the pathogenesis of PCD.
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