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Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid
Sheng-Kwei Song1, Joong Hee Kim, Shiow-Jiuan Lin
1Department of Chemistry, Washington University, St. Louis, MO 63130, USA. victor@wuchem.wustl.edu
Neurobiology of Disease
|April 2, 2004
Summary
Alzheimer
Area of Science:
- Neuroscience
- Biomedical Imaging
- Neurodegenerative Diseases
Background:
- Alzheimer's disease (AD) pathology affects both gray and white matter.
- White matter injury is increasingly recognized in AD progression.
Purpose of the Study:
- To investigate white matter integrity in a mouse model of Alzheimer's disease using diffusion tensor imaging (DTI).
- To assess white matter changes associated with amyloid-beta (Abeta) deposition over time.
Main Methods:
- Utilized transgenic PDAPP mice overexpressing amyloid precursor protein (APP).
- Employed diffusion tensor magnetic resonance imaging (DTI) to analyze white matter microstructure.
- Compared DTI parameters between young and old PDAPP mice and age-matched controls.
Main Results:
- Significant differences in DTI parameters were observed in old PDAPP mice compared to old controls.
- No significant DTI parameter differences were found between young PDAPP and control mice.
- DTI detected white matter injury correlating with Abeta deposition in PDAPP mice.
Conclusions:
- White matter injury is associated with the progression of AD-like pathology in PDAPP mice.
- Diffusion tensor imaging is a sensitive tool for detecting white matter alterations in Alzheimer's disease models.
- Increasing amyloid-beta levels over time contribute to white matter damage in AD.