Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glutamate and anxiety.

Veerle Bergink1, Harold J G M van Megen, Herman G M Westenberg

  • 1Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, B01.206, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. v.bergink@azu.nl

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|April 2, 2004
PubMed
Summary

Glutamate receptors in the brain offer potential for anxiety treatment. Fine-tuning these systems, particularly metabotropic glutamate receptors, shows promise for developing effective anxiety disorder therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prenatal inflammation and postpartum anxiety: Findings from a prospective pregnancy cohort in New York City.

Journal of affective disorders·2026
Same author

Bipolar Disorder Incidence During Pregnancy and in the Postpartum Period: A Population-Based Study.

Bipolar disorders·2026
Same author

Genetic architecture of postpartum psychosis: from common to rare genetic variation.

Molecular psychiatry·2026
Same author

Reporting of Sex Specific Findings Leads to Altered Conclusions Regarding Potential Protective Effects of Doxycycline for Schizophrenia.

The American journal of psychiatry·2026
Same author

Psychiatric History and Postpartum Depression: The Mediating Role of Obstetric Complications.

Acta psychiatrica Scandinavica·2026
Same author

Examining the association between prenatal inflammation and postpartum depression in a large, prospective pregnancy cohort in New York City.

Brain, behavior, and immunity·2026

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Glutamate's complex actions in the limbic system are crucial for anxiety.
  • These actions are mediated by ionotropic and metabotropic glutamate receptors.

Purpose of the Study:

  • To explore the potential of modulating glutamate receptors for anxiety treatment.
  • To identify promising therapeutic targets within the glutamatergic system.

Main Methods:

  • Review of preclinical studies on compounds targeting NMDA, AMPA/kaïnate, and metabotropic glutamate receptors.
  • Analysis of emerging strategies for fine-tuning glutamatergic neurotransmission.

Main Results:

  • NMDA and AMPA/kaïnate antagonists show limited clinical utility due to adverse effects.

Related Experiment Videos

  • Modulators of the glycine site and AMPA receptor compounds are emerging.
  • Metabotropic glutamate receptor agonists and antagonists demonstrate significant promise.

    • Conclusions:

    • Selective modulation of glutamate activity is essential for effective anxiety disorder treatment.
    • Metabotropic glutamate receptors represent a particularly promising target for anxiolytic drug development.