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Cognitive functioning in late-life bipolar disorder.

Ariel G Gildengers1, Meryl A Butters, Karen Seligman

  • 1Information Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA. gildengersag@upmc.edu

The American Journal of Psychiatry
|April 2, 2004
PubMed
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Elderly individuals with bipolar disorder often experience cognitive impairments, even when symptoms are stable. This research highlights significant neuropsychological deficits in older adults with bipolar disorder.

Area of Science:

  • Geriatric Psychiatry
  • Neuropsychology
  • Bipolar Disorder Research

Background:

  • Bipolar disorder (BD) is a chronic mental health condition.
  • Cognitive deficits are common in BD but less studied in elderly populations.
  • Understanding cognitive function in older adults with BD is crucial for management.

Purpose of the Study:

  • To characterize cognitive functioning in elderly patients diagnosed with bipolar disorder.
  • To compare cognitive performance in older adults with BD to a healthy control group.

Main Methods:

  • 18 euthymic patients (aged 60+) with Bipolar I or II disorder were assessed.
  • Cognitive tests included the Mini-Mental State Examination (MMSE), Mattis Dementia Rating Scale, and Executive Interview.
  • Performance was compared to 45 age- and education-matched controls without mood disorders.

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Main Results:

  • Nearly half of bipolar subjects (44%) scored below average on the MMSE.
  • Over half of bipolar subjects (56%) showed deficits on the Mattis Dementia Rating Scale.
  • 17% of bipolar subjects had executive function impairments on the Executive Interview.

Conclusions:

  • A substantial number of elderly patients with bipolar disorder exhibit neuropsychological deficits.
  • These deficits persist even during clinically euthymic periods.
  • Findings underscore the need for cognitive assessment and targeted interventions in older adults with BD.