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Updated: Aug 23, 2026
Microdialysis of Ethanol During Operant Ethanol Self-administration and Ethanol Determination by Gas Chromatography
Published on: September 5, 2012
Development of an experimental system for evaluation of stress effect on ethyl alcohol metabolism using
Akiko Maruko1, Yosuke Ohtake, Atsuko Suzuki
1Department of Radiopharmacy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
Abstract:
We attempted to develop an experimental system for evaluation of stress effect on ethyl alcohol metabolism by the radiorespirometric analysis using [(14)C]ethyl alcohol. Each rat was immobilized in an adjustable restraint device for 3 h. The excretion of (14)CO(2) in the breath was significantly decreased by restraint stress. The liver alcohol dehydrogenase activity was also decreased by restraint stress. We think that radiorespirometric analysis may be useful for the evaluation of stress effect on real metabolism of ethyl alcohol in the liver.
