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Updated: Aug 25, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
5-Demethoxyfumagillol, a potent angiogenesis inhibitor isolated from Aspergillus fumigatus
Deukjoon Kim1, Jaeki Min, Soon Kil Ahn
1Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Korea. deukjoon@plaza.snu.ac.kr
Abstract:
A novel angiogenesis inhibitor, 5-demethoxyfumagillol (1), was obtained by isolation, purification and saponification of cultured broth of Aspergillus fumigatus. The structure was assigned as (3R,4R,6R)-4-[(2R,3R)-2-methyl-3-(3-methyl-but-2-enyl)-oxiranyl]-1-oxa-spiro[2,5]octan-6-ol (1) by spectroscopic analysis and confirmed by independent synthesis from fumagillol (3). In addition, 6-O-(chloroacetylcarbamoyl)-5-demethoxyfumagillol (7) showed a potential anti-angiogenic activity in CAPE cells in vitro.
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