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Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
Cutaneous intravascular lymphoma following extravascular lymphoma of the lung
Carlo Tomasini1, Mauro Novelli, Renata Ponti
1Department of Biomedical Science and Human Oncology, Second Dermatologic Clinic, University of Turin, Turin, Italy. ctomasini@molinette.piemonte.it
Abstract:
Intravascular lymphoma (IL) is a rare aggressive disease characterized by exclusive or predominant accumulation of malignant lymphoid cells within the lumina of small arteries, veins and capillaries. We describe a 74-year-old woman with IL presenting in the skin as asymptomatic teleangiectatic plaques on the thighs. The cutaneous neoplasm developed 18 months after an extravascular large B cell lymphoma of the lung and heralded its relapse. No neurologic symptoms were present during the course of the fatal disease. Immunophenotypic and immunogenotypic studies confirmed a unique B cell subtype. This case of IL is unusual for the association with an extravascular B cell lymphoma suggesting a link between the two diseases.
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