Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protecting Self-Esteem01:27

Protecting Self-Esteem

204
Self-esteem, a central component of psychological well-being, is actively maintained through various cognitive and behavioral strategies. Individuals employ specific mechanisms to preserve a positive self-concept and mitigate threats to their self-worth, particularly in contexts involving social evaluation or personal feedback. Four primary techniques are commonly used to sustain self-esteem.Manipulating AppraisalsOne prominent strategy involves manipulating appraisals from others. Individuals...
204
What is the Immune System?01:38

What is the Immune System?

127.3K
Overview
127.3K
Defining Psychology01:24

Defining Psychology

7.7K
Psychology is the scientific discipline dedicated to understanding both observable behavior and the internal mental processes underlying such behavior. It aims to comprehend human nature and apply this understanding to solve practical problems, enhance well-being, and improve societal outcomes. An example of psychology's application is the study of prosocial behavior, such as why and under what conditions individuals might help strangers in need. This process involves describing observed...
7.7K
Zones of Protection01:16

Zones of Protection

788
In power systems, the entire setup is divided into protective zones to isolate faults and protect the rest of the network. These zones include generators, transformers, buses, transmission lines, distribution lines, and motors. Each zone can be visualized as a separate room in a house, with each room protected by its own circuit breaker.
Protective zones are defined by closed dashed lines, containing one or more components. A key characteristic of these zones is the strategic placement of...
788
Protection of Alcohols02:31

Protection of Alcohols

8.0K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.0K
Radial System Protection01:23

Radial System Protection

433
Radial systems employ time-delay overcurrent relays to reduce load interruptions. When a fault occurs, the nearest breaker opens first, while upstream breakers remain closed due to longer delay settings. This approach ensures minimal disruption to the rest of the system.
In a radial system with a fault downstream of the third breaker, ideally, only the third breaker will open, isolating the fault and interrupting the load connected beyond it. The second breaker has a longer delay setting,...
433

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term antibody dynamics challenge the paradigm of lifelong homotypic immunity to dengue virus.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Addressing the elephant in the room: Proceedings of the third annual Dengue Endgame Summit.

PLoS neglected tropical diseases·2026
Same author

Early individualized risk prediction using clinical data for children during the febrile phase of dengue in outpatient settings in Vietnam and Thailand.

PLOS digital health·2026
Same author

Linking multiple serological assays to infer dengue virus infections from paired samples using mixture models.

PLoS computational biology·2025
Same author

Afucosylation of anti-dengue IgG is associated with enhanced susceptibility to dengue virus infection postvaccination.

Science translational medicine·2025
Same author

Antibody responses to Japanese encephalitis virus and dengue virus serotype 2 in children from an orthoflavivirus endemic region after IMOJEV vaccination.

PLoS neglected tropical diseases·2025
Same journal

Julie Zikherman receives the ASCI/Marian W. Ropes, MD, Award.

The Journal of clinical investigation·2026
Same journal

Targeted degradation of MDM2 overcomes feedback regulation of p53 signaling in Merkel cell carcinoma models.

The Journal of clinical investigation·2026
Same journal

SGLT2 inhibitors enhance ketogenesis by acting as allosteric activators of the mitochondrial enzyme HMGCS2.

The Journal of clinical investigation·2026
Same journal

MDM2 degraders for Merkel cell carcinoma: round peg in a round hole.

The Journal of clinical investigation·2026
Same journal

Ammonia in the crosshairs: microbial targets for metabolic dysfunction-associated steatohepatitis prevention.

The Journal of clinical investigation·2026
Same journal

Molecular mechanisms regulating cGAS/STING activation in health and disease.

The Journal of clinical investigation·2026
See all related articles

Related Experiment Video

Updated: Jan 26, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.1K

Dengue: defining protective versus pathologic immunity.

Alan L Rothman1

  • 1Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. alan.rothman@umassmed.edu

The Journal of Clinical Investigation
|April 2, 2004
PubMed
Summary
This summary is machine-generated.

Dengue virus infections pose a growing global health challenge, with vaccine development hindered by complex immune responses. Understanding how prior infections with different dengue virus serotypes affect subsequent disease severity is key to creating effective vaccines.

More Related Videos

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.7K
Visualizing Dengue Virus through Alexa Fluor Labeling
09:11

Visualizing Dengue Virus through Alexa Fluor Labeling

Published on: July 9, 2011

14.4K

Related Experiment Videos

Last Updated: Jan 26, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.1K
Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.7K
Visualizing Dengue Virus through Alexa Fluor Labeling
09:11

Visualizing Dengue Virus through Alexa Fluor Labeling

Published on: July 9, 2011

14.4K

Area of Science:

  • Virology
  • Immunology
  • Public Health

Background:

  • Dengue virus (DENV) poses a significant and expanding global public health threat.
  • The development of an effective dengue vaccine remains a critical unmet medical need.
  • Sequential infections with distinct DENV serotypes can influence disease severity.

Purpose of the Study:

  • To review the dual role of heterologous immunity in dengue virus sequential infections.
  • To explore how beneficial and detrimental effects of heterologous immunity impact disease outcomes.
  • To highlight the importance of understanding these immune effects for optimal dengue vaccine design.

Main Methods:

  • Literature review of studies on dengue virus serotypes and sequential infections.
  • Analysis of immunological mechanisms underlying heterologous immunity in dengue.
  • Synthesis of current knowledge on dengue vaccine-induced immune responses.

Main Results:

  • Sequential DENV infections can elicit both protective and exacerbating immune responses.
  • Heterologous immunity, while sometimes beneficial, can lead to antibody-dependent enhancement (ADE) in subsequent infections.
  • Understanding the balance of these effects is crucial for predicting vaccine efficacy.

Conclusions:

  • A comprehensive understanding of heterologous immunity is essential for developing safe and effective dengue vaccines.
  • Predicting optimal vaccine-induced immune responses requires consideration of prior DENV exposure.
  • Further research into the nuances of dengue virus immunology is critical for public health.