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Related Experiment Videos

Maintenance of a normal meal-induced decrease in plasma ghrelin levels in children with Prader-Willi syndrome.

C Bizzarri1, A E Rigamonti, G Giannone

  • 1Unità Operativa Complessa di Pediatria e Adolescentologia, Ospedale Bambino Gesù, IRCCS, Palidoro-Roma, Italy.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|April 2, 2004
PubMed
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Ghrelin, a hormone that stimulates appetite, is suppressed by meals in Prader-Willi syndrome (PWS) children, unlike in adults. This suggests ghrelin regulation is present in childhood but declines with age, impacting PWS obesity.

Area of Science:

  • Endocrinology
  • Pediatrics
  • Genetics

Background:

  • Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHS-R1a), stimulating GH secretion and food intake.
  • Prader-Willi syndrome (PWS) is a genetic disorder characterized by syndromic obesity, with abnormal appetite and GH secretion.
  • Ghrelin dysregulation is hypothesized to contribute to obesity in PWS.

Purpose of the Study:

  • To investigate meal-induced suppression of ghrelin in children with Prader-Willi syndrome (PWS).
  • To compare ghrelin response to meals in PWS children, obese children, and normal controls.
  • To explore the developmental regulation of ghrelin in PWS.

Main Methods:

  • Assayed overnight fasting and post-breakfast (120 min) ghrelin levels in 7 PWS children, 7 morbidly obese children, and 5 normal controls.

Related Experiment Videos

  • Analyzed statistical differences in ghrelin levels between groups and before/after meals.

    • Main Results:

    • Fasting ghrelin levels were lower in obese children compared to controls and PWS children.
    • Meals slightly suppressed ghrelin in controls but failed to suppress it in obese children.
    • Meals significantly suppressed ghrelin levels in PWS children (p < 0.01).

    Conclusions:

    • Meal-induced ghrelin suppression is present in PWS children, contrasting with PWS adults.
    • This suggests ghrelin regulation is operative in childhood but deteriorates with age in PWS.
    • The findings imply that impaired ghrelin regulation contributes to the progressive hyperphagia and obesity seen in PWS.