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Related Experiment Videos

Acute exercise has no effect on ghrelin plasma concentrations.

A Schmidt1, C Maier, G Schaller

  • 1Department of Medicine III, University of Vienna, and Ludwig Boltzmann Institute for Experimental Endocrinology, Vienna.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|April 2, 2004
PubMed
Summary

Exercise significantly boosts growth hormone (GH) secretion, but this study found that the stomach hormone ghrelin does not play a role in this exercise-induced GH response in healthy males.

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Area of Science:

  • Endocrinology
  • Exercise Physiology
  • Metabolism

Background:

  • Exercise is a known stimulus for growth hormone (GH) secretion.
  • Hypothalamic peptides like GH-releasing hormone (GHRH) and somatostatin are key regulators of exercise-induced GH release.
  • The role of ghrelin, a stomach-derived peptide with GH-releasing properties, in this context is not fully understood.

Purpose of the Study:

  • To investigate the relationship between exercise intensity and GH and ghrelin plasma concentrations.
  • To determine if ghrelin participates in regulating the GH response to varying exercise workloads in healthy young men.

Main Methods:

  • Eight healthy young male volunteers performed treadmill exercise at 50%, 70%, and 90% of their maximum oxygen consumption (VO2max) on separate occasions.

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  • Blood samples were collected to measure GH and ghrelin plasma concentrations during exercise.
  • Maximal exercise capacity was determined individually for each participant.

    • Main Results:

    • GH serum concentrations significantly increased at all tested exercise intensities.
    • Maximal GH response varied with exercise duration and intensity.
    • Plasma ghrelin concentrations remained unchanged across all exercise workloads.

    Conclusions:

    • Ghrelin does not appear to be involved in the regulation of exercise-induced GH secretion in healthy males.
    • The GH response to exercise is likely mediated by other neuroendocrine mechanisms, independent of ghrelin levels.