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Updated: Aug 25, 2026
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
Advances in molecular carcinogenesis: current and future use of mouse models to screen and validate molecularly
Anita F W Frijhoff1, Claudio J Conti, Adrian M Senderowicz
1The University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas, USA.
Abstract:
Survival of patients with advanced solid tumors has not significantly improved over the past 30 years. Although molecularly targeted anticancer drugs offer promise, few drugs make it through the end of the Food and Drug Administration approval process. Animal models that more closely resemble human carcinogenesis may bridge the gap between preclinical success and benefits for patients. We discuss pros and cons of several mouse models, including genetically engineered mice that each represent different aspects of human cancer, and the screening of targeted drugs in these models.
Insights
Improving advanced solid tumor survival requires better cancer models. Genetically engineered mouse models offer a promising preclinical approach for screening targeted anticancer drugs, potentially bridging the gap to patient benefit.
Area of Science:
- Oncology
- Translational Medicine
- Preclinical Research
Background:
- Survival rates for advanced solid tumors have stagnated for three decades.
- Limited success of molecularly targeted anticancer drugs in clinical trials.
- Need for improved preclinical models that better mimic human cancer development.
Purpose of the Study:
- To evaluate the utility of various mouse models for human cancer research.
- To discuss the advantages and disadvantages of genetically engineered mouse models (GEMMs).
- To assess the application of GEMMs in screening targeted anticancer therapies.
Main Methods:
- Review and comparison of different mouse models of human carcinogenesis.
- Analysis of genetically engineered mice representing diverse aspects of human cancer.
- Evaluation of drug screening methodologies using these preclinical models.
Main Results:
- Genetically engineered mouse models (GEMMs) offer a closer resemblance to human cancer.
- GEMMs can recapitulate specific genetic alterations and pathological features of human tumors.
- These models facilitate the evaluation of targeted therapies in a more relevant context.
Conclusions:
- Mouse models, particularly GEMMs, are crucial for advancing cancer drug development.
- Improved preclinical models can enhance the translation of targeted therapies to clinical success.
- Further development and utilization of GEMMs are essential for improving patient survival in advanced solid tumors.
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